Development and Validation of a Nomogram for Predicting Prognosis to Immune Checkpoint Inhibitors Plus Chemotherapy in Patients With Non-Small Cell Lung Cancer.

BACKGROUND: Immune checkpoint inhibitors (ICIs) plus chemotherapy improved the prognosis of patients with non-small cell lung cancer (NSCLC); however, reliable prognostic biomarkers are lacking. We explored factors associated with prognosis and developed a predictive model. METHODS: We retrospectively analyzed 130 consecutive stage IIIA-IVB NSCLC patients treated with ICIs combined with chemotherapy. Cox univariate and multivariate proportional hazards regression analyses were used to identify prognostic factors associated with progression-free survival (PFS). A nomogram was developed based on key factors in the training cohort (n = 86) and evaluated in the validation cohort (n = 44). According to the nomogram-based total point scores, we divided patients into low- and high-risk groups. RESULTS: In the training cohort, bone metastases (p = 0.017) and an increased derived neutrophil-to-lymphocyte ratio (p = 0.018) were significantly associated with poor PFS, while smoking (p = 0.007) and programmed death-ligand 1 (PD-L1) ≥50% (p = 0.001) were associated with improved PFS. A nomogram based on these factors was developed to predict PFS at 3, 6, and 12 months. The C-index of the nomogram to predict PFS was 0.725 (95% CI: 0.711-0.739) in the training cohort and 0.688 (95% CI: 0.665-0.711) in the validation cohort. The area under the curve (AUC) exhibited an acceptable discriminative ability, and calibration curves demonstrated a consistency between the actual results and predictions. In the training cohort, the median PFS (mPFS) was 12.3 and 5.7 months in the low- and high-risk groups, respectively (p < 0.001). In the validation cohort, the mPFS was 12.6 and 6.2 months in the low- and high-risk groups, respectively (p = 0.021). CONCLUSIONS: A predictive nomogram was developed to help clinicians assess prognosis early for advanced NSCLC patients who received ICI plus chemotherapy.

[Study on crystalline and properties of N', N-Bis (n-butyl)-3, 4, 9, 10-perylene tetracarboxylic diimide].

N', N-Bis(n-butyl)-3,4,9,10-perylene tetracarboxylic diimide was synthesized, purified and crystallized, then IR, element analysis and X-ray diffraction were tested. The spectrum of UV-Vis absorption (maximum absorption peak at 524. 80 nm), fluorescence emission (maximum emission intensity at 539.0 nm) and stokes displacement (15 nm) of the compound in DMF were analyzed. The UV-Vis absorption spectrum between 400 and 700 nm in a film can indicate that alpha-crystal has much stronger absorption peaks than beta-crystal and that red shift of maximum absorption occurs (545 to 580 nm) when beta-crystal is changed into alpha-crystal. It is obvious that CPS of alpha, beta-crystal are respectively 2 508 at 26.0 degrees and 1 891 at 25.2 degrees in the X-ray diffraction pattern. The functional separate photoreceptors of alpha, beta-crystal as charge generation material were made, and photoconductivity properties were tested after charging the sample and then using spectral light of 532 nm formed by a band path filter.